The Urban Institute conducted an implementation and participant-outcomes evaluation of the Alaska Native Science & Engineering Program (ANSEP). ANSEP is a multi-stage initiative designed to prepare and support Alaska Native students from middle school through graduate school to succeed in science, technology, engineering, and math (STEM) careers. The Brief summarizes the findings of the full-length Report, providing an overview of the major takeaways from the evaluation project. The findings inform ANSEP’s programming and provide lessons for other STEM education programs that serve underrepresented minorities nationwide.